Hypotensive Effect of Chemical Constituents from Aloe barbadensis

Rubeena Saleem; Shaheen Faizi; Bina Shaheen Siddiqui; Muhammad Ahmed; Syed Ahmed Hussain; Aamer Qazi; Ahsana Dar; Syed Iqbal Ahmad; Mahmood Hussain Qazi; Shamim Akhtar; Syed Nazrul Hasnain

doi:10.1055/s-2001-18348

Planta Med 2001; 67(8): 757-760
DOI: 10.1055/s-2001-18348

Letter

Hypotensive Effect of Chemical Constituents from Aloe barbadensis

Rubeena Saleem^1,*, Shaheen Faizi² , Bina Shaheen Siddiqui² , Muhammad Ahmed¹ , Syed Ahmed Hussain¹ , Aamer Qazi¹ , Ahsana Dar² , Syed Iqbal Ahmad¹ , Mahmood Hussain Qazi¹ , Shamim Akhtar³ , Syed Nazrul Hasnain³

¹ Dr. H.M.I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan
² H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan
³ Department of Biochemistry, University of Karachi, Pakistan

Abstract

Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of elgonica dimer A (1).

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References

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Dr. Rubeena Saleem

Dr. H.M.I. Institute of Pharmacology and Herbal Sciences

Hamdard University

Karachi-74600

Pakistan

Email: rs127pk@yahoo.com

Fax: +92-21 699-6002, 664-11755